BARD1 deletion in a patient with suspected hereditary colorectal cancer

BARD1 deletion in a patient with suspected hereditary colorectal cancer

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Abstract Deleterious germline variants in the BRCA1-associated ring domain (BARD1) gene moderately elevate breast cancer risk; however, their Baby Bottle potential association with other neoplasms remains unclear.Here, we present the case of a 43-year-old female patient diagnosed with sigmoid colon adenocarcinoma whose maternal family members met the Amsterdam Criteria II for 808 Lynch syndrome.Comprehensive multigene panel testing revealed a heterozygous BARD1 exon 3 deletion.